Products Description

Chemical formula: C42H70O35.xH2O
CAS number: 68168-23-0
Application: Pharmaceutical raw materials and intermediates

Cyclodextrin (β-cyclodextrin, abbreviated as β-CD) is a product formed by the acid hydrolysis and cyclization of starch. It can encapsulate various compound molecules, enhancing the stability of the encapsulated substances to light and heat, and changing the physical and chemical properties of the encapsulated substances. β-cyclodextrin has the advantages of high selectivity, non-toxicity, edible nature, non-hygroscopicity, excellent chemical stability, and ease of separation. It can adsorb non-polar substances such as cholesterol, as its inner diameter can just accommodate one cholesterol molecule. The principle mainly lies in the slight interfacial activity of cholesterol, which will aggregate at the oil-water interface, facilitating the encapsulation of β-cyclodextrin in the aqueous phase, forming a water-insoluble β-cyclodextrin-cholesterol complex. Through centrifugation, it can be separated from the food. The removal rate of cholesterol increases with the increase of β-cyclodextrin concentration. If too much β-cyclodextrin is added, due to the competition between molecules, the removal rate of cholesterol will decrease. Using more β-cyclodextrin will also reduce the yield of the food and leave more β-cyclodextrin. Application in the food industry. Cyclodextrin has functions such as protecting some substances from oxidation, light, heat, volatilization, and solidification. Therefore, it can be used as a multifunctional food additive.

1. Widely used in the pharmaceutical excipient industry. It is mainly used to enhance the stability of drugs, prevent drug oxidation and decomposition, improve the solubility and bioavailability of drugs, reduce the toxic side effects of drugs, and mask the odor and stench of drugs.
2. In the food manufacturing field, it is mainly used to eliminate odors, improve the stability of flavoring agents, fragrances and pigments, enhance emulsification ability and moisture-proof ability.
3. Improving the taste of food. It is a good stabilizer and flavor modifier for the pharmaceutical, food and cosmetic manufacturing industries.

Products Application

As stabilizers, processing aids, etc. In China, β-cyclodextrin is permitted for use in baked foods and soups, with maximum usage amounts of 2.5g/kg and 100g/kg respectively. ① It is used to encapsulate volatile flavors to stabilize them. ② Due to its surfactant properties, it is used for emulsifying oily foods. ③ It is used in soy products, cheese curds, lamb, etc., where it can remove off-flavors such as beaniness, bitterness, and fishiness. ④ It is used in making solid wines and fruit juice powders, etc. ⑤ It is used in fruit and vegetable canned foods: it can prevent the production of white turbidity in the juice.

1. During food processing and preservation, β-CD can prevent the volatilization of various spices, oils, spices, and other volatile substances, thus maintaining the unchanged aroma of the food over a long period. β-CD can also keep the stability of nutrients such as oxidizable, light-sensitive, and heat-sensitive pigments, amino acids, and vitamins. 2. β-CD can remove the fishy and meaty odors and other unpleasant tastes in food after adding vitamins B and other nutrients, enhancing the palatability of the food, and also improve the taste of sweeteners such as saccharin and cyclamate. 3. For beverages with high oil content, such as ice cream, coffee beverages, and other emulsified foods, β-CD can make them form long-term stable emulsions. If used in combination with food emulsifiers, the emulsifying effect will be even better. 4. β-CD can allow food preservatives and preservatives to release slowly, improving the preservation effect and extending the shelf life of the food.
Application of β-Cyclodextrin in Medicine: 1. β-CD can prevent the volatilization of drugs such as nitroglycerin, borneol, and naphthalene; prevent the oxidation, light-induced deterioration, and heat-induced degradation of drugs such as chloramphenicol, vitamins, amino acids, and other hormone drugs, and improve the stability of drugs. 2. β-CD can increase the water solubility of insoluble drugs; β-CD can increase the solubility of isoproterenol by 200 times, facilitating absorption in the body and improving the bioavailability. 3. β-CD can reduce the side effects of drugs such as thiamylal and benzodiazepines, and remove the bitter taste of the drugs. 4. β-CD can act as an immune inducer, inhibiting the proliferation of HIV. New plant growth regulators and pesticide enhancers 5. β-CD can regulate plant hormones, enhancing biological effects, enabling early fruit ripening, increasing sugar content, adding pigments, and doubling the yield. 6. β-CD can improve the stability of pesticides that are prone to decomposition and volatilization to light and heat, improving the therapeutic effect and reducing the pollution of pesticides to the surrounding atmospheric environment.
High Value of β-Cyclodextrin in Daily Chemical Industry: β-Cyclodextrin can prevent cosmetic whitening agents from damaging the oxidation and browning of blood acid, improving the whitening effect, and reducing irritation; using β-CD as an effective component to prepare deodorants: the deodorization effect is excellent, with no side effects. Cyclodextrin can also encapsulate certain odorous substances, achieving deodorization. For example, there is an anti-tumor oral drug called "5-fluorouracil", which has a bad smell, but after being mixed with cyclodextrin, the bad smell is masked.