Mannitol is an isomer of sorbitol, and its effects are mainly reflected in food, industry and medical aspects. Food: Often used as chewing gum, maltose, rice cakes and other food anti-stick powder and sweetener.


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I. Basic Information
1. Chemical Properties
Chemical Name: D-Mannitol
Molecular Formula: C₆H₁₄O₆
CAS No.: 69-65-8
Molecular Weight: 182.17 g/mol
Structure Type: Hexahydric alcohol
2. Physical Properties
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder |
| Sweetness | 50-70% of sucrose |
| Melting Point | 166-169℃ |
| Solubility (25℃) | Water: 18g/100ml |
| Caloric Value | 1.6kcal/g |
| Optical Rotation | [α]D²⁰ +23° to +25° |
3. Chemical Properties
Non-reducing polyol
Acid/alkali resistant (stable at pH 3-8)
Maillard reaction inert
Forms complexes with metal ions
II. Application Scenarios
1. Pharmaceutical (USP Grade)
Injections:
Osmotic diuretic (20% solution)
Reduces intracranial/intraocular pressure
Oral Preparations:
Tablet filler (direct compression)
Chewable tablet base
Diagnostic Reagents:
Renal function tests
Bowel cleansing agent
2. Food Industry (E421)
Functional Uses:
Sugar-free sweetener
Anti-caking agent (chewing gum)
Ice cream texture modifier
Specialty Foods:
Diabetic foods
Anti-caries candies
Low-calorie chocolate
3. Industrial Uses
Chemical Industry:
Surfactant raw material
Polyester resin modifier
Personal Care:
Toothpaste humectant
Body powder ingredient
Scientific Research:
Microbial culture media
Cryoprotectant
III. Technical Specifications
| Grade | Purity | Moisture | Heavy Metals | Residue on Ignition |
|---|---|---|---|---|
| Pharma | ≥98% | ≤0.5% | ≤10ppm | ≤0.1% |
| Food | ≥96% | ≤1% | ≤20ppm | ≤0.3% |
| Industrial | ≥92% | ≤2% | ≤50ppm | ≤0.5% |
IV. Safety Specifications
ADI: Not specified (JECFA)
Injection Contraindication: Severe pulmonary edema
Oral Limit: ≤20g/day (prevents diarrhea)
Storage: RH<60%, below 25℃
Note: Different crystallization methods (cooling/evaporation) affect particle morphology and flowability.









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